Cornell University Study Finds Antiviral Enzymes Key Promoters Of Early Bladder Cancer

The study suggested that the antiviral enzymes responsible for mutating the DNA of cancer and normal cells are the main promoters of early bladder cancer development.

Study in US: A study by researchers at the New York Genome Center and Weill Cornell Medicine has found insights into how bladder cancer starts and develops. These insights highlight the need for new therapeutic strategies.

They found that the antiviral enzymes which mutate normal and cancerous cell DNA are the main promoters of early bladder cancer development.

Cornell University Research On Bladder Cancer Highlights

The scientists focused on the urothelial carcinoma - the main form of bladder cancer. The scientists collected cells of the same patients during pre-malignant and malignant stages and used advanced computational methods and whole-genome sequencing to map common DNA mutations.

Co-senior author Dr. Bishoy Faltas, the Gellert Family-John P. said, “Our findings define new fundamental mechanisms driving bladder cancer evolution – mechanisms that we can now think about targeting with therapies.”

The study provided strong evidence that APOBEC3 enzymes are responsible for early mutations. “The exact role of APOBEC3-induced mutations in cancer initiation hasn’t been clear,” said Faltas.

“But we found that these mutations appear early in urothelial cancer, occurring even in pre-malignant urothelial tissue,” added Faltas.

Cornell researchers to create “resilience hubs”

Historical Black community - Residents of Southside are one of the three communities joining forces with Cornell researchers to create “resilience hubs”. It will include facilities to support communities during crises and disasters due to pressing issues of the current time such as pandemics or climate changes.

The Cornell team along with the communities is all set to have brainstorming sessions on October 17, 2024.

Alistair Hayden, assistant professor of practice in the Department of Public and Ecosystem Health in the College of Veterinary Medicine said, “These resilience hubs are driven by what the community wants, and driven by what hazards they experience, what vulnerabilities they have in their communities, what priorities they have.”

“It has to be a two-way street. There must be building trust and understanding and listening to the needs in these vulnerable communities. What we really need is a replicable playbook, a workbook that other communities can pick up and customize,” said Rebecca Morgenstern Brenner, senior lecturer in the Cornell Jeb E. Brooks School of Public Policy.

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