Comparing Genes, Proteins, and Genomes (Bioinformatics III)
- Offered byCoursera
Comparing Genes, Proteins, and Genomes (Bioinformatics III) at Coursera Overview
Duration | 22 hours |
Start from | Start Now |
Total fee | Free |
Mode of learning | Online |
Difficulty level | Intermediate |
Official Website | Explore Free Course  |
Credential | Certificate |
Comparing Genes, Proteins, and Genomes (Bioinformatics III) at Coursera Highlights
- Shareable Certificate Earn a Certificate upon completion
- 100% online Start instantly and learn at your own schedule.
- Course 3 of 7 in the Bioinformatics Specialization
- Flexible deadlines Reset deadlines in accordance to your schedule.
- Beginner Level
- Approx. 22 hours to complete
- English Subtitles: Arabic, French, Portuguese (European), Italian, Vietnamese, German, Russian, English, Spanish
Comparing Genes, Proteins, and Genomes (Bioinformatics III) at Coursera Course details
- Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different.
- In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins.
- In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question.
- Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST.
Comparing Genes, Proteins, and Genomes (Bioinformatics III) at Coursera Curriculum
Week 1: Introduction to Sequence Alignment
(Check Out Our Wacky Course Intro Video!)
From Sequence Comparison to Biological Insights
The Alignment Game and the Longest Common Subsequence Problem
The Manhattan Tourist Problem
The Change Problem
Dynamic Programming and Backtracking Pointers
From Manhattan to the Alignment Graph
Course Details
Week 1 FAQs (Optional)
Week 1 Quiz
Week 2: From Finding a Longest Path to Aligning DNA Strings
From Global to Local Alignment
Week 2 FAQs (Optional)
Week 2 Quiz
Week 3: Advanced Topics in Sequence Alignment
Penalizing Insertions and Deletions in Sequence Alignment
Space-Efficient Sequence Alignment
Multiple Sequence Alignment
Week 3 FAQs (Optional)
Week 3 Quiz
Week 4: Genome Rearrangements and Fragility
Transforming Men Into Mice
Sorting by Reversals
Breakpoint Theorem
Rearrangements in Tumor Genomes
2-Breaks
Week 4 FAQs (Optional)
Week 4 Quiz
Week 5: Applying Genome Rearrangement Analysis to Find Genome Fragility
Breakpoint Graphs
2-Break Distance Theorem
Rearrangement Hotspots in the Human Genome
Synteny Block Construction
Week 5 FAQs (Optional)
Week 5 Quiz
Week 6: Bioinformatics Application Challenge
Comparing Genes, Proteins, and Genomes (Bioinformatics III) at Coursera Admission Process
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