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DTU - Introduction to Industrial Bioprocess Development 

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Introduction to Industrial Bioprocess Development
 at 
Coursera 
Overview

Duration

15 hours

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Total fee

Free

Mode of learning

Online

Difficulty level

Beginner

Official Website

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Credential

Certificate

Introduction to Industrial Bioprocess Development
 at 
Coursera 
Highlights

  • Earn a Certificate upon completion
    Coursera Labs
    Flexible Schedule
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Introduction to Industrial Bioprocess Development
 at 
Coursera 
Course details

More about this course
  • The course begins with a brief description of some basic properties of microorganisms and general aspects related to their use in bioprocesses at industrial scale
  • The course includes a group of lectures dedicated to some stages that precede fermentation; specifically, media formulation, sterilization, preservation of microorganisms and inoculum preparation
  • The main characteristics of predominant types of industrial bioreactors along with process parameters that need to be controlled in stirred tank reactors are also covered in one of the modules of the course
  • Since the expansion of a bioprocess from a lab scale to an industrial scale is of considerable importance, an additional lecture dedicated to this topic is presented. The last part of the course provides a general overview of downstream processing, addressing processes used for the removal of cells from the culture medium, methods for the disruption of cells, and isolation of the target bioproduct
  • By the end of the course, learner should:
  • Be able to identify the fundamental difference between the two basic cell types: eukaryotic and prokaryotic cells
  • Distinguish the main steps of the brewing process
  • Identify some important steps in recombinant protein production
  • Define the different stages of the industrial production of bioethanol
  • Distinguish the main characteristics of the three fermentation modes: batch, continuous and fed-batch
  • Define important parameters of the continuous fermentation mode
  • Identify bioprocesses where fed-batch fermenters are used and for how long can a fed-batch process be run
  • Identify how defined and undefined fermentation media are formulated
  • Discuss the role that key components of culture media play in bioconversion processes
  • Recognize the importance in avoiding microbial contamination
  • Describe chemical and physical sterilization methods
  • Distinguish the main characteristics of common techniques of cell preservation
  • Recognize factors that are commonly considered to obtain an inoculum suitable for fermentation at industrial scale
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Introduction to Industrial Bioprocess Development
 at 
Coursera 
Curriculum

Module 1 - Fundamentals of Microbial Bioreaction Design

Welcome lecture

Properties of microorganisms

The development of fermentation - Part 1

The development of fermentation - Part 2

The development of fermentation - Part 3

About the Course Team

Suggested literature

Fundamentals of Microbial Bioreaction Design - Graded Quiz

Module 2 - Mass Balances and Kinetics

Batch

Chemostat

Fed-batch

Suggested literature

Mass Balances and Kinetics - Graded Quiz

Module 3 - Upstream Processing

Medium formulation

Sterilization

Preservation of microorganisms

Inoculum development

Suggested literature

Upstream Processing - Graded Quiz

Module 4 - Bioreactor Engineering

Types of bioreactors

Parameters affecting bioprocesses in Stirred Tank Reactors

Bioprocess scale-up

Suggested literature

Bioreactor Engineering - Graded Quiz

Module 5 - Downstream Processing

Product recovery

Primary isolation

Case study

Suggested literature

Downstream Processing - Graded Quiz

Introduction to Industrial Bioprocess Development
 at 
Coursera 
Admission Process

    Important Dates

    May 25, 2024
    Course Commencement Date

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    Introduction to Industrial Bioprocess Development
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