UNIGE - Precision Medicine
- Offered byCoursera
Precision Medicine at Coursera Overview
Duration | 29 hours |
Start from | Start Now |
Total fee | Free |
Mode of learning | Online |
Difficulty level | Intermediate |
Official Website | Explore Free Course  |
Credential | Certificate |
Precision Medicine at Coursera Highlights
- Earn a shareable certificate upon completion.
- Flexible deadlines according to your schedule.
Precision Medicine at Coursera Course details
- This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues.
- From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, experts will walk you through the many aspects of precision medicine, from the bench to the bedside and to population health.
- Designed for students with a bachelor-level training in life sciences, this course will also be useful for professionals who are increasingly expected to deal with precision medicine, including primary care physicians and other first-line healthcare professionals, cancer and non-communicable diseases specialists, public health policy and decision makers, as well as biomedical researchers and drug developers.
- Experts from the multiple domains of genetics and genomics, oncology, pharmacology, data sciences, ethics, and biomedical research will provide you with a comprehensive, multi-faceted overview of precision medicine, richly illustrated with practical examples and clinical case studies, and peppered with formative evaluations.
- Whether you are interested or intrigued by topics such as ?genethics?, the analysis of exome sequencing, precision diabetes management, hereditary cancers, the ongoing revolution of genetic technologies, genome-exposome interactions, the pharmacogenetics of opioids, data deidentification, blockchain-base patient-consent documentation, or proteomics and biomarkers, this course will explain the concepts, offer insights and present concrete examples, thus providing you with an overall understanding of the rapidly evolving field of precision medicine.
Precision Medicine at Coursera Curriculum
Monogenic Diseases
Trailer
Welcome to the course
Introduction to the module
Human genome variabilty and phenotype consequences 1
Human genome variability and phenotype consequences 2
Medical consultation (part 1)
Exome sequencing analysis
What are the options? discussion between the physician and the biologist
Medical consultation (part 2)
Rare genetic disorder and precision medicine
Ethical, Legal and Social Implications (ELSI)
Conclusion
How assessments work
Syllabus
List of Teachers
Bibliographic References
Human genome variability and phenotype consequences
Medical consultation part 1
Exome sequencing analysis
Rare genetic disorder and precision medicine
Ethical, Legal and Social Implications (ELSI)
Monogenic disease
Complex Diseases
Introduction
Genetics of complex disorders
Environmental determinant
Diabetes management today
Diabetes risk assessment part 1
The key points - answers to the discussion by the expert (part 1)
Precision approaches in diabetes
Diabetes risk assessment (part 2)
The key points - answers to the discussion by the expert (part 2)
Conclusion
Genetics of complex disorders
Environmental determinants
How to evaluate the disease risk (part 1)
How to evaluate the disease risk (part 2)
Complex disease
Cancer
Somatic mutation theory of cancer
Synthetic lethality and oncogene addiction
Clinically-orientated analysis
Introduction to clinical ethics
Objectives of precision oncology
Tumor classification
What is a biomarker?
Somatic bioinformatics pipelines
Molecular tumor board
Ethical and societal implications
Sporadic, familial and hereditary cancer
Family history in oncology
Genetic counselling in oncology
Main hereditary cancer syndromes
Case study 1 - part 1
Case study 1 - part 2
Case study 2 - part 1
Case study 2 - part 2
Further reading
Sommatic mutation theory of cancer
Synthetic lethality and oncogene addiction
Introduction to clinical ethics
Objectives of precision oncology
Tumor classification
What is a biomarker?
Somatic bioinformatics pipeline
Molecular tumor board
Ethical and societal implications
Sporadic, familial and hereditary cancer
Family history in oncology
Genetic counselling in oncology
Main hereditary cancer syndromes
Case Study 1 - part 1
Case Study 1 - part 2
Case Study 2 - part 1
Cancer
Health and Prevention
Introduction to the module
The Revolution of Genetic Technologies
Main Opportunities of Genomics
Genomics and Complex Chronic Diseases
The Revolution of Environmental Technologies
Genome-Exposome Interaction
Big Data
Validity and Massive Information
Restitution, Unintended Findings and Actionable Variants
Patients' Willingness to Discuss their Genomic Information
Evidence-Based Precision Medicine
Conclusion
New Technologies and Personalized Health: Opportunities and Challenges
Tyrell and all.
Testing the opportunities discussed
Testing the illustration discussed
Testing the concept of behaviome
Testing the understanding of the Tyrell and all. results
Big Data
Testing challenges of translating genomics into clinical care
Health and prevention
Pharmacogenomics and Drug Development
Introduction to the module
Variability in drug response
Drug metabolism
Role of Transporters in Drug Disposition
Case - Pharmacogenomics of Statins
Other Cardiovascular Case Studies
Pharmacogenomics of opioids
Tools for clinicians and patients
Current Methods to Identify Pharmacogenomics Variants
Phenotyping in the lab
Drug development 1
Drug development 2
Pharmacovigilance
Pharmacoeconomics and pharmacogenomics
Citizen Centered Consent
Data deidentification
Conclusion and Future Perspectives
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
Table of Pharmacogenetic Associations
Case study: antiaggregant and HIV
Case Study: the example of oxycodone
Variability in drug response
Drug metabolism
Role of Transporters in Drug Disposition
Pharmacogenomics of statins
Other cardiovascular diseases
Pharmacogenomics of opioids
Tools of clinicians and patients
Current Methods to Identify Pharmacogenomics Variants
Phenotyping in the lab
Drug development 1
Drug development 2
Pharmacovigilance
Pharmacoeconomics and pharmacogenomics
Citizen Centered Consent
Data Deidentification
Evaluation of the module
Research
Introduction to the module
First Steps of a Research Project
Sample Collection, Biobanking and Data Generation/Recording
Data Quality Control and Data Analysis
Data dissemination, databases and publication
Explanations by the expert
Explanation by the expert: patient stratification in traumatic brain injury
Explanations by the expert: Steroid Signatures in Toxicology
Conclusion of the module
Conclusion of the course in Precision Medicine
Estimating the causal tissues for complex traits and diseases
Abstract section of the article
First steps of a research project
Sample collection, biobanking and data generation/recording
On Data videos above (2)
Questions on published article
Questions on abstract - please read abstract before answering
Patient stratification in traumatic brain surgery
Steroid signatures in toxicology
Research
Precision Medicine at Coursera Admission Process
Important Dates
Other courses offered by Coursera
Student Forum
Anything you would want to ask experts?
Useful Links
Know more about Coursera
Know more about Programs
- Medical Courses
- Paramedical Courses
- Clinical Research
- Medical Transcription
- Perfusion Technology
- Diabetology
- Forensic Medical Science
- Dialysis Technology
- Cardiovascular Technology
- Cath Lab Technology
- BSc Operation Theatre Technology
- BSc in Perfusion Technology
- Physician Assistant
- BSc Physician Assistant
- BSc in Respiratory Care Technology