Toxicology 21: Scientific Applications
- Offered byCoursera
Toxicology 21: Scientific Applications at Coursera Overview
Duration | 96 hours |
Total fee | Free |
Mode of learning | Online |
Difficulty level | Intermediate |
Official Website | Explore Free Course  |
Credential | Certificate |
Toxicology 21: Scientific Applications at Coursera Highlights
- Shareable Certificate Earn a Certificate upon completion
- 100% online Start instantly and learn at your own schedule.
- Flexible deadlines Reset deadlines in accordance to your schedule.
- Intermediate Level
- Approx. 96 hours to complete
- English Subtitles: French, Portuguese (European), Russian, English, Spanish
Toxicology 21: Scientific Applications at Coursera Course details
- This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report ?Toxicity Testing in the 21st Century: A Vision and a Strategy.? We present the latest developments in the field of toxicology?the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.
Toxicology 21: Scientific Applications at Coursera Curriculum
Module 1
Welcome to Module 1
Course Introduction
Introduction
Center for Alternatives to Animal Testing
Toxicology of the Fifteenth to Twentieth Centuries
Toxicology for the Twenty-First Century
Historical Perspective
The First Report: Toxicity Testing for Assessment of Environmental Agents
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation
useful links
supporting reading material
Supporting reading material
Module 1 Quiz
Module 2
Welcome to Module 2
Adverse Outcome Pathways (AOPs)
Exposure-Based Chemical Prioritization
ER Bioactivity Model
US EPA Endocrine Disruptor Screening Program (EDSP)
Modeling of Hazard and Organ Manifestation
Building a Signature for Vascular Disruption
Testing the Vascular Disruption Signature
Virtual Tissue Model: Vascular Development
Functional Vascular Development Assays
Supporting Reading Material
Useful links
Supporting Reading Material
Useful links
Module 2 Quiz
Module 3
Welcome to Module 3
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology
The Concept of the Human Toxome Project
Concept and Tool Devlopment
Progress
Conclusions and Prospectives
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?
Omics Technologies and High-Throughput Data
Interpreting Omics Data
PoT Examples and Conclusions
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)
Supporting reading materials
Supporting reading material
Module 3 Quiz
Module 4
The Need, and Opportunity, for a New Approach to Toxicology, Including Predictive Tools
The Concept of Toxicological (Biological) Pathways, e.g., ?Adverse Outcome Pathways,? Is the Basis of Predictive Toxicology
Introduction to the OECD AOP Framework
Building, Evaluating, and Using AOPs in Safety Decisions
Online Tools Available to Everyone, Including an Online AOP Course
Welcome to Module 4
Introduction to Read-Across
Good Read-Across Practice
Supporting Read-Across with Biological Data
Creating a Database of Toxicity
Creating an Automated Tool for Read-Across
Paradigm Shift in Toxicology
2D In Vitro Cell Culture
3D In Vitro Cell Cultures
Organ-on-a-Chip
Supporting reading material
Supporting reading material
Useful links
Module 4 Quiz
Mid-term exam
Welcome to Module 5
MicroRNA and Epigenetics
Epigenetics and Environment
MicroRNA: Biogenesis and Functions
Role of MicroRNA in Development
MicroRNA in Toxicology
Supporting reading material
Module 5 Quiz
Module 6
Welcome to Module
Physiologically Based Biokinetic Modeling
Application of QIVIVE to in Vitro Testing
Challenges for Conducting QIVIVE
Quantitative in Vitro to in Vivo Extrapolation
Definition of Biometry/Biostatistics and Revisiting Some Statistical Basics
Types of Tox21 Data and Data Mining of External Data Sources
Bioinformatics Tools for the Interpretation of Tox21 Data
Supporting reading material
Supporting reading material
Useful links
Module 6 Quiz
Module 7
Welcome to Module 7
Why Integrated Testing Strategies?
What is an Integrated Testing Strategy?
How to Compose Integrated Testing Strategies
Strategies for Integrated Testing Strategies
Quality Assurance of integrated Testing Strategies
Legal Background
Economic Background
Tox-21c for Drug Safety
Green Toxicology as Non-regulatory Tox-21c Approaches
Conclusions and Prospects
Supporting reading material
Supporting reading material
Module 7 Quiz
Final Exam
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