GATE Bio Technology Syllabus: Exam Dates (OUT), Check Paper Combination, Pattern, and More

Linear Algebra

Matrices and Determinants | Systems of Linear Equations | Eigen Values and Eigen Vectors

Calculus

Limits | Continuity and Differentiability | Partial Derivatives | Maxima and Minima | Sequences and Series | Test for Convergence

Differential Equations

Linear and Non-Linear First Order ODEs | Higher Order ODEs with constant coefficients | Cauchy’s and Euler’s equations | Laplace Transforms

Probability and Statistics

Mean, Median, Mode and Standard Deviation | Random Variables | Poisson, Normal, and Binomial Distributions | Correlation and Regression Analysis

Numerical Methods

Solution of Linear and Non-Linear Algebraic Equations | Integration by Trapezoidal and Simpson’s Rule | Single-Step Method for Differential Equations 

Biochemistry

Biomolecules - structure and function | Biological membranes - structure, membrane channels and pumps | Molecular motors | Action Potential and Transport Processes | Enzymes- Classification, Catalytic and Regulatory Strategies | Enzyme Kinectics - Michaelis - Menten Equation | Enzyme Inhibition - Competitive, Non-Competitive and Uncompetitive Inhibition

Microbiology

Bacterial Classification and Diversity | Microbiological Ecology - Microbes in Marine, Fresh water and Terrestrial ecosystems | Viruses - Structure and Classification | Methods in Microbiology | Microbial Growth and Nutrition | Antibiotics and Antimicrobial Resistance

Immunology

Innate and Adaptive Immunity | Humoral and Cell-Mediated Immunity | Primary and Secondary Lymphoid Organs | Polyclonal and Monoclonal Antibody | Immunization and Vaccines

Genetics and Evolutionary Biology

Mendelian Inheritance | Gene Interaction | Extra Chromosomal Inheritance | Genetic Disorders | Genetic Drift | Species and Speciation | Recombination and Chromosome Mapping

Cell Biology

Prokaryotic and Eukaryotic Cell Structure | Cell Cycle and Cell Growth Control | Cell Signalling and Signal Transduction | Extra-Cellular Matrix

Molecular Biology

Molecular Structure of Genes and Chromosomes | Mutations and Mutagenesis | Non-Coding and Micro RNA | DNA Damage and Repair

Engineering Principles Applied to Biological Systems

Material and Energy Balances for reactive and non-reactive systems | Recycle, Bypass, and Purge process | Degree of Reduction | Electron Balance and Theoretical Oxygen Demand

Classical Thermodynamics and Bioenergetics

Laws of Thermodynamics | Solution Thermodynamics | Phase Equilibria | Reaction Equilibria | Legend Binding | Oxidation and Reduction Reactions

Transport Processes

Newtonian and non-Newtonian Fluids | Fluid Flow - Laminar and Turbulent | Molecular Diffusion and Film Theory | Conductive and Convective Heat Transfer | LMTD | Heat Exchangers

Bioreaction Engineering

Rate Law | Zero and First Order Kinetics | Ideal Reactors - Batch, Mixed Flow, and Plug Flow | Enzyme Immobilization | Kinetics of Cell Growth | Batch | Fed-Batch and Continuous Processes | Microbial and Enzyme Reactors | Optimization and Scale-Up

Upstream and Downstream Processing

Media Formulation and Optimization | Sterilization of Air and Media | Filtration - Membrane filtration | Cell Disruption | Extraction, Absorption, and Drying

Instrumentation and Process Control

Pressure | Temperature and Flow Measurement Devices | First order and Second order systems | Feedback and Feed Forward Control | Types of Controllers - Proportional, Derivative, and Integral Control, Tuning of Controllers

Plants

Totipotency | Regeneration of Plants | Tissue Culture and Cell Suspension Culture System | Hairy Root Culture | Plant Products of Industrial Importance | Protoplast | Transgenic Plants - Direct and Indirect Methods of gene transfer Techniques | Selection Marker and Reporter Gene | Plastid Transformation

Animals

Culture media composition and growth conditions | Animal Cell and Tissue Preservation | Kinetics of Cell Growth | Hybridoma Technology | Stem cell technology | Animal Cloning

Microbes

Production of Biomass and Primary/Secondary Metabolites - Biofuels, Bioplastics, Industrial Enzymes | Clinical, Food, and Industrial Microbiology | Screening Strategies for new products

Recombinant DNA Technology

Restriction and Modification Enzymes | Ti Plasmid, Bacterial, and Yeast Artificial Chromosomes | Expression Vectors | Gene Isolation and Cloning | Transposons and Gene Targeting

Molecular Tools

Polymerase Chain Reaction | DNA/RNA labelling and sequencing | DNA fingerprinting | Site-directed mutagenesis | Biosensing and Biosensors

Analytical Tools

Principles of microscopy - light, electron, fluorescent and confocal | Electrophoresis | Immunoblotting | Flow Cytometry | Whole genome and CHIP sequencing

Computational Tools

Bioinformatics resources and search tools | Sequence and Structure Databases | Genomics | Proteomics | Metabolomics | Gene Prediction | Metagenomics | Metabolic Engineering and Systems Biology

Engineering Mathematics

Advanced Engineering Mathematics by HK Dass (S.Chand publication)

Essential Engineering Mathematics by Erwin Kreyszig

General Biology

Biotechnology GATE by B.M. Agarwal, Akanksha Singhal, Vidhika Goel (Arihant Publication)

Genetics, Cellular and Molecular Biology

Molecular Biology of the Cells by Bruce Alberts

Fundamentals of Biological Engineering

Biotechnology GATE by B.M. Agarwal, Akanksha Singhal, Vidhika Goel (Arihant Publication)

Bioprocess Engineering and Process Biotechnology

Bioprocess engineering bySchuler and Kargi, PM Doran

Plant, Animal and Microbial Biotechnology

Plant Biotechnology by Bhojwani and HS Chawla

Animal Biotechnology by Ian Freshney

Recombinant DNA Technology and Other Tools in Biotechnology

Recombinant DNA: Principles and Methodologies  by J.K. Jayaraman