IIT Kanpur's Research Unveils Promising Paths in Cancer, Brain Disorder Treatment

IIT Kanpur's recent biomedical research delves into G protein-coupled receptors and the chemokine receptor D6, unveiling potential treatment of cancer and various brain disorders like Alzheimer’s, Parkinson’s, and schizophrenia. Check complete details here 

The researchers at Indian Institute of Technology (IIT) Kanpur made a big discovery in medical science. Their study of G protein-coupled receptors and chemokine receptor D6 in the body shed new light on potential treatment of cancer and brain problems like Alzheimer’s, Parkinson’s, and schizophrenia. The findings of the new research from IIT Kanpur will help in a greater understanding of the working of these receptors and lead to the development of new therapeutic approaches and targeted treatments for conditions such as Alzheimer’s, which affects over 50 million people worldwide, and cancer, responsible for over 10 million deaths annually. 

This project saw the team from IIT Kanpur working with researchers from Japan, the Republic of Korea, Spain, and Switzerland. The researchers used a high-tech method called cryogenic-electron microscopy (cryo-EM) to create detailed three-dimensional images of the receptors. 

Prof S Ganesh, Director, IIT Kanpur said, “The path-breaking research opens the doors to a new era in targeted medicine that can deliver solutions for cancer and neurological conditions for millions across the world. These diseases, which cause immense suffering and economic burden, could see a new era of effective treatment developed based on these findings! The success of this research project is also a testament to our successful collaboration with scientists across the world.”

The research team from the Laboratory of GPCR Biology, IIT Kanpur included Prof Arun K Shukla, Department of Biological Sciences and Bioengineering and Principal Investigator GPCR Lab; Ramanuj Banerjee, Post-Doctoral Fellow; Manish Yadav, Post-Doctoral Fellow; Ashutosh Ranjan, Post-doctoral fellow, currently Faculty at Lucknow University; Jagannath Maharana, PhD scholar now heading to the Max Planck Institute of Molecular Physiology as a post-doctoral fellow; 

Madhu Chaturvedi, PhD scholar now heading to UCSF as a post-doctoral fellow; Parishmita Sarma, PhD student; Vinay Singh, Project JRF, now headed to IMPRS on Cellular Biophysics, Frankfurt as a PhD student; Sayanatan Saha, Project Research Fellow; and, Gargi Mahajan, Project Research Fellow.

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