IIT Roorkee Researchers Decode Bacterial Antibiotic Resistance Mechanisms; Check Details Here
The IIT Roorkee study uncovers that the bacterial protein L, D-transpeptidase A (LdtA) enables bacteria to evade rod complex-targeting antibiotics like mecillinam.
IIT Roorkee Researchers Decode Bacterial Antibiotic Resistance
A recent study conducted by the research group led by Prof. Ranjana Pathania at the Indian Institute of Technology (IIT) Roorkee has uncovered significant insights into bacterial resistance mechanisms. The study identifies a specific bacterial protein, L,D-transpeptidase A (LdtA), as a crucial factor that enables bacteria to evade the effects of antibiotics targeting the rod complex, including mecillinam.
Mecillinam is a widely used antibiotic, particularly effective in treating urinary tract infections (UTIs) caused by E. coli. However, the research highlights that when LdtA levels are elevated, bacteria can develop resistance to this critical antibiotic, rendering it less effective. These findings pave the way for deeper understanding to overcome antibiotic resistance in bacterial infections.
This study underscores the critical need to understand the mechanisms behind bacterial resistance to antibiotics, demonstrating that targeting specific proteins could transform treatment strategies. These findings pave the way for exploring combination therapies that enhance antibiotic effectiveness, helping to combat infections that could otherwise become resistant and untreatable.
The study revealed that prolonged exposure of bacteria to a newly developed rod complex-targeting compound, IITR07865, over 30 days led to the emergence of specific mutations. These mutations, combined with the overproduction of the protein L, D-transpeptidase A (LdtA), enhanced the bacteria's resilience. As a result, the bacteria became resistant not only to IITR07865 but also to mecillinam, an antibiotic typically used to target the bacterial cell wall.
Prof. Ranjana Pathania remarked, “Our research brings us closer to dismantling the defenses bacteria use to evade antibiotics. This breakthrough is a vital step toward developing smarter and more resilient treatment strategies to protect global health and preserve the power of antibiotics for future generations."
The findings of this study have been published in the prestigious ACS Infectious Diseases journal, highlighting its importance to the global scientific community. Professor Kamal Kishore Pant, Director of IIT Roorkee, commented, “Our work on antibiotic resistance underscores IIT Roorkee’s commitment to addressing critical challenges in healthcare. This discovery not only adds to our understanding of resistance mechanisms but also points towards innovative treatment options for bacterial infections, safeguarding public health for the future.”
Q: Â Is B.Sc. at IIT Roorkee a good choice?
Based on the reviews and feedback from students and alumni, here's a summary of the pros and cons:
Pros:
* Excellent Placement Record: 100% placement record with top companies like Microsoft, Goldman Sachs, Oracle, Adobe, and many more offering salaries between INR8-INR43 Lacs per annum.
* Highly Qualified Faculty: Professors are knowledgeable and helpful, with many holding Ph.D.s in their respective fields.
* Relevant Curriculum: Course curriculum is highly relevant, providing immense opportunities in different fields of the industry.
* Good Infrastructure: Modern classrooms, air-conditioned libraries, and well-maintained hostels with amenities like Wi-Fi, LAN, gym, and sports facilities.
* Campus Life: Campus life is lively with multiple fests, sports events, and clubs catering to various interests.
* Internship Opportunities: Many students secure internships with leading companies, with 70-90% of students participating in internships.
Cons:
* Limited Faculty Availability: Not all professors are approachable, and some might not be readily available for guidance.
* Placement Focus on IT Sector: While the placement record is impressive, the focus tends to lean towards the IT sector, leaving limited options for core engineering students.
* Food and Mess Issues: Feedback suggests that the mess food is average, and some students face issues with the quality of meals.
In conclusion, B.Sc. at IIT Roorkee appears to be a good choice for those seeking a strong foundation in mathematics and computer science, with excellent placement prospects and a vibrant campus life. However, it's essential to weigh the potential limitations, particularly regarding faculty availability and the focus on the IT sector.
Q: Â Is IIT Roorkee good for BTech?
By paying a total tuition fee amount of INR 8 lakh, students have the opportunity to score salary packages up to INR 27.94 LPA (the highest salary package during 2023 placements). Further, the average and median package offered during IIT Roorkee placement process of 2023 stood at INR 18.34 LPA and INR 18.09 LPA. In terms of ROI, the deal looks decent. In addition to this, the college ranks under the top 10 best institutes in the country for Engineering by NIRF 2022. Hence, BTech from IIT Roorkee is a good idea.
Q: Â Is it worth pursuing B.Arch at IIT Roorkee?
Based on the feedback from students and alumni, here are some key points to consider:
* High Placements: IIT Roorkee's B.Arch programme has a excellent placement record, with almost 90% of students getting placed every year. Top companies like Microsoft, Meta, J.P. Morgan, and Accenture visit the campus for placements, offering packages ranging from 8-45 LPA.
* Good Faculty: The faculty members are highly qualified, with many holding Ph.D.s. While some may not be enthusiastic about teaching, others are exceptional and provide valuable guidance and mentorship.
* Infrastructure: The college has modern infrastructure, including state-of-the-art laboratories, libraries, and sports facilities. The hostels are comfortable, with basic amenities like Wi-Fi, gym, and mess.
* Research Opportunities: The college encourages research and innovation, providing opportunities for students to participate in projects and internships.
* Festivals and Events: IIT Roorkee hosts various festivals and events throughout the year, including Thomson, Tech-Fest, and cultural programs.
However, some students mentioned the following challenges:
* Course Load: The coursework can be heavy, with frequent assignments and projects.
* Hostel Food: Some students were dissatisfied with the hostel food, citing poor quality and limited options.
* Teaching Style: A few faculty members may not be engaging or effective teachers.
Overall, while there may be some drawbacks, the majority of students agree that pursuing B.Arch at IIT Roorkee is a great decision, considering its strong reputation, excellent placements, and good faculty. With hard work and dedication, students can make the most of their experience at the college.
Here's a summary in bullet points:
* Excellent placement records
* Good faculty with Ph.D. qualifications
* Modern infrastructure and facilities
* Research opportunities and internships
* Variety of festivals and events
* Heavy coursework and project load
* Poor hostel food
* Teaching style varies among faculty members
Remember to weigh these pros and cons carefully to decide whether IIT Roorkee's B.Arch programme is right for you.
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Sanjana Surbhi has over five years of experience in the online education sector. Drawing from her tenure with ed-tech companies, she infuses her work with a wealth of knowledge from the education realm, lending an i... Read Full Bio
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